Retrosternal gentamicin-collagen sponge does not reduce the incidence of mediastinitis in cardiac surgery
نویسندگان
چکیده
Methods Between September 2011 and June 2012 a total of 1372 consecutive patients underwent cardiac surgery at our institution. Of these patients, 1048 underwent elective procedures via median sternotomy, met inclusion criteria and were enrolled into the study. The complete cohort was prospectively divided into two registries. In treatment registry (543 patients), a collagen sponge containing 130 mg gentamicin was implanted retrosternal before sternal closure. In control registry 2 (505 patients) the sponge was not used. Primary endpoint was freedom from mediastinitis according to CDC criteria on the 30th postoperative day. Secondary endpoint was freedom from surgical site infection of any kind.
منابع مشابه
Impact of Gentamicin - Collagen Sponge (Collatamp) on the incidence of sternal wound infection in high risk cardiac surgery patients
OBJECTIVE Local delivery of prophylactic antibiotic to the wound site with an implanted, reabsorbable, gentamicin-containing collagen sponge (Collatamp) is a strategy that has been claimed to prevent sternal wound infection after cardiac surgery. The purpose of this study was to review our experience with Collatamp in cardiac surgery patients deemed at high risk for sternal wound infection. M...
متن کاملDoes a gentamicin-impregnated collagen sponge reduce sternal wound infections in high-risk cardiac surgery patients?
OBJECTIVES Sternal wound infections occurring after cardiac surgery have a critical impact on morbidity, mortality and hospital costs. This study evaluated the efficacy of a gentamicin-collagen sponge in decreasing deep sternal-wound infections in high-risk cardiac surgery patients. METHODS We conducted a quasi-experimental single-centre prospective cohort study in diabetic and/or overweight ...
متن کاملEffectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials
INTRODUCTION Gentamicin impregnated collagen sponges are licensed for use after cardiac surgery in over 50 countries but their effectiveness at preventing sternal wound infections (SWIs) remains uncertain. The aim of this meta-analysis was to assess the current evidence for effectiveness of such sponges at preventing SWIs in patients after cardiac surgery. METHODS A systematic search of the l...
متن کاملGentamicin-impregnated collagen sponge for preventing sternal wound infection after cardiac surgery
The frequency of sternal wound infection (SWI) after cardiac surgery ranges from 0.5% to 8% and is associated with significant morbidity, mortality, and treatment cost. Perioperative antibiotic prophylaxis is not sufficient to fully prevent the contamination of the surgical access site. One of the most effective methods for the prevention of wound infection seems to be the use of gentamicin-imp...
متن کاملEffect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial.
CONTEXT Despite the routine use of prophylactic systemic antibiotics, sternal wound infection still occurs in 5% or more of cardiac surgical patients and is associated with significant excess morbidity, mortality, and cost. The gentamicin-collagen sponge, a surgically implantable topical antibiotic, is currently approved in 54 countries. A large, 2-center, randomized trial in Sweden reported in...
متن کامل